Thu, 14 Dec 2017

Development and evaluation of Propranolol hydrochloride buccal mucoadhesive gel using Natural Mucoadhesive Agent obtained from the Fruits of Ficus carica L.

 

G D Deshmukh*1, M Mohan Varma2, S Y Manjunath3

 

1. Department of Pharmacy, Sumandeep Vidyapeeth University, Pipariya, Tal Waghoiya, Dist Vadodara (Gujarat) -391760, India,

2. Shri Vishnu College of Pharmacy, Vishnupur, Bhimavaram, West Godavari District Andhra Pradesh- 534202, India.

3. Srikrupa Institute of Pharmaceutical Sciences, Vill: Velkatta, Mdl: Kondapak, RD: Siddipet, Medak, 502 277

 


 

ABSTRACT

 

Buccal delivery is considered to be an important alternative to the peroral route for the systemic administration of  drugs. The paper describes formulation of buccal mucoadhesive gel from Ficus carica mucilage using prorpranolol hyderochloride. Propranolol, a nonselective beta adrenergic blocking agent, has been widely used in the treatment of hypertension, angina pectoris, and many other cardiovascular disorders. It is highly lipophilic and is almost completely absorbed after oral administration. However, much of the drug is metabolized by the liver during its first passage through the portal circulation; on average, only about 25% reaches the systemic circulation. The conventional oral dosage form of this drug has low bioavailability due to high first pass metabolism, so it is modified as buccal drug dosage form to improve bioavailability and for the localized drug release because of high vascularity and drugs diffusing across the membrane have easy access to the systemic circulation via internal jugular vein. In present research mucilage is extracted from Ficus carica and studeuied for there mucoadhesive properties. The gel were evaluated by different parameters such as zeta potential, viscosity, Gel strength, Drug Release, Mechanism of drug release & histological study.

Keyword: Buccal delivery, mucoadhesive, Ficus carica mucilage


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