Thu, 14 Dec 2017

NANOPARTICULATE DRUG DELIVERY SYSTEM USING DRUG POLYMER AND APTAMER CONJUGATION

Maulik Acharya*1, Mandev Patel1, Jignyasha Raval2

 

1. K. B. Raval College of Pharmacy, Shertha, Gandhinagar-382423, Gujarat, India

2. Shree S. K. Patel College of Pharmaceutical Edu. & Res, Kherva, Mehsana, Gujarat, India


ABSTRACT

 

In ancient Greek ‘Nano’ means dwar. Nanotechnology is the creation and utilization of materials, devices, and systems through the control of matter on the nanometer-length scale, i.e. at the level of atoms, molecules, and supramolecular structures. These technologies have been applied to improve drug delivery and to overcome some of the problems of drug delivery for cancer treatment. The magic of nanoparticles mesmerize everyone because of their multifunctional character and they have given us hope for the recovery from this disease. Nanoparticles can be used to deliver hydrophilic drugs, hydrophobic drugs, proteins, vaccines, biological macromolecules, etc. They can be formulated by aptamer conjugation for targeted delivery to the lymphatic system, brain, arterial walls, lungs, liver, spleen, or made for long-term systemic circulation. Therefore, numerous protocols exist for synthesizing nanoparticles based on the type of drug used and the desired delivery route. In modern medicine technologies the oral administration of solid forms is the preferred route for drug delivery. Thus, in pharmaceutical applications, size, shape and morphology of the solid particles are important because they can affect the solubility as well as bioavailability of the drug particles.

 

Keywords: Nanoparticles, Bioavailability, Aptamer, Targeted drug delivery system


[PDF]  Viewed: 1318  Downloaded: 192
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter