Thu, 14 Dec 2017

A REVIEW ON SYNTHESIS AND BIOLOGICAL ACTIVITY OF HETEROCYCLIC COMPOUNDS BEARING 1, 3, 5-TRIAZINE LEAD MOIETY

Deepak Kumar Basedia1*, B. K. Dubey 1, Birendra Shrivastava 2

 

1. T.I.T. College of Pharmacy, Anand nagar, Post-Piplani, BHEL, Bhopal- 462021 (M.P.), India.

2.School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, Jaipur-(Raj.), India


ABSTRACT

 

Triazine is the chemical species of six-membered heterocyclic ring compound with three nitrogens replacing carbon-hydrogen units in the benzene ring structure. The names of the three isomers indicate which of the carbon-hydrogen units on the benzene ring position of the molecule have been replaced by nitrogens, called 1,2,3-triazine, 1,2,4-triazine, and 1,3,5-triazine respectively. Symmetrical 1, 3, 5-triazine is the common.  Triazines are prepared from cyanic acid amide by trimerization (1, 3, 5-triazine). Pyridine is the aromatic nitrogen heterocyclic compound having only one nitrogen, and diazines are with 2 nitrogen atoms, triazine having three nitrogen and tetrazines are with 4 nitrogen atoms on the benzene ring system. Triazines are weak base. Triazines have much weaker resonance energy than benzene, so nucleophilic substitution is preferred than electrophilic substitution. Heterocyclic bearing a symmetrical s-triazines or 1, 3, 5-triazines moieties, represent an interesting class of compounds possessing a wide spectrum of biological activities such as anti-cancer, antiviral, fungicidal, insecticidal, bactericidal, herbicidal and antimicrobial, antimalarial agents. They also find applications as dyes, lubricants and analytical reagents.

 

Key words: Triazine, Nucleophilic substitution, Cyanuric chloride, 1, 3, 5-triazine, s- Triazine

 


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