Thu, 14 Dec 2017

PHYTOPHARMACOLOGICAL EVALUATION OF PERGULARIA DAEMIA AS AN ANTI-INFLAMMATORY AGENT

Vyas Bhavin A*1, Vyas Ruchi B2, Joshi Shrikant V1,  Shah Payal D1, Vyas Heta G1, Santani Dev D3

 

1. Dept of Pharmacology, Maliba Pharmacy College, Gopal Vidyanagar, Tarsadi (Guj), India

2. Dr. Dayaram Patel Pharmacy College, Bardoli, India

3. Rofel, Shri G. M. Bilakhia College of Pharmacy, Vapi, India


ABSTRACT

 

The whole-plant, Pergularia daemia (Family: Asclepediaceae), extract (50% alcohol) was investigated for phytochemical, physico-chemical parameters and its anti-inflammatory activity. Preliminary organic analysis revealed the presence of alkaloids, flavonoid, steroid, triterpenoid and phenolic compounds in the extract. Physiochemical studies revealed that total ash is 13.62%, acid insoluble ash is 1%, alcohol soluble extractive value is 17.6%, water soluble extractive value is 30.4% and loss on drying at 105°C is 10.6%.  The anti-inflammatory activity was evaluated using carrageenan-induced paw edema (acute inflammation) and chronic models like; cotton pellet granuloma and carrageenan air pouch granuloma. Oral administration of the extract (50 and 100 mg/kg) exhibited significant anti-inflammatory activity in acute and chronic models (p < 0.01) of inflammation. In conclusion, present investigation established specific identities that will be useful in identification and authentication of the raw drug and pharmacological evidences to support the folklore claim that P. daemia is used as anti-inflammatory agent.

 

Key words: Pergularia daemia, physicochemical, carrageenan, cotton-pallet


[PDF]  Viewed: 1976  Downloaded: 204
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter