Thu, 14 Dec 2017

SPECTROPHOTOMETRIC DETERMINATION OF CLOPIDOGREL BISULFATE IN PHARMACEUTICAL FORMULATIONS

Suhas Gurav*1, Rohan Tembare1,  Vishali Salunkhe1, Devprakash1, Senthilkumar G.P. 1

 

Bharathi College of Pharmacy, Bharthinagara, K. M. Doodi, Maddur, Mandya, Karnataka, India


ABSTRACT

 

A simple, sensitive and accurate spectrophotometric method was developed in ultraviolet region for the estimation of Clopidogrel bisulfate in pure drug, pharmaceutical formulation. Linear response obtained was in the concentration range of 25-50 µg/ml with correlation coefficient of 0.999 in 0.1 N HCl. Excellent recovery proved that the method was sufficiently accurate. There is no interference from any common pharmaceutical additives and diluents. Results of the analysis were validated by recovery studies according to ICH Q2B guidelines.

 

Keywords: Clopidogrel bisulfate, UV- Spectrophotometry, recovery, accuracy.


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