Thu, 14 Dec 2017

DEVELOPMENT AND VALIDATION OF DERIVATIVE UV-SPECTROPHOTOMETRIC METHODS FOR QUANTITATIVE ESTIMATION OF ILOPERIDONE IN BULK AND PHARMACEUTICAL DOSAGE FORM

R. Venkatamahesh,*1 R. Venkatesha Perumal1, C. Jose Gnana Babu1, R. Revathi1, S Muneer1, K.P.Channabasavaraj1.

 

1. Bharathi College of Pharmacy, Bharathi Nagara, Mandya (District), Karnataka, India


ABSTRACT

 

First and second order derivative UV-Spectrophotometric methods have been developed and validated for the estimation of Iloperidone in bulk and its tablet formulations. The solutions of standard and sample were prepared in methanol. The Iloperidone solution was showed the maximum absorbance at 262nm and 248nm for the first and second order UV-Spectrophotometric methods respectively. Beer’s law was obeyed in the concentration range of 4- 12 μg / ml with r2 value 0.999 for both the methods. These methods were tested and validated for various parameters according to ICH guidelines. The precision expressed as relative standard deviation and was found within the range of 0.13 % to 1.7 % for the both methods. Limit of detection was 0.0133 μg/ml (first order), 0.0216 μg/ml (second order) and  limit of quantification was found to be 0.0403 μg/ml (first order), 0.0657 μg/ml (second order). Recovery of Iloperidone was found to be within the range of 99.51 – 100.16 % for the two methods. The proposed methods were successfully applied for the determination of Iloperidone in tablet formulations. In addition, the proposed methods are simple, easy to apply, low cost, and requires relatively inexpensive instruments.

 

Keywords: Iloperidone, Method Validation, Derivative UV-Spectrophotometric methods.


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