Thu, 14 Dec 2017

DESIGN AND IN-VITRO EVALUATION OF SUSTAINED-RELEASE MATRIX TABLETS OF TIMOLOL MALEATE

Architha M*1, Kishore R2, Madhu babu D3, Prabhakar Reddy1

 

1. Department of Pharmaceutics, St. Peter’s Institute of Pharmaceutical Sciences, Warangal, A.P.

2. National Institute of Pharmaceutical Education and Research ( NIPER ), Balanagar, Hyderabad, A.P, India

3. Dept. of Pharmaceutics, JSS College of Pharmacy, JSS University, Mysore, India.


ABSTRACT

 

The aim of the present study was to prepare and characterize twice-daily sustained-release matrix tablets of Timolol maleate (TM) using different concentrations of hydrophilic Hydroxypropylmethylcellulose (HPMC K100M CR) alone and its combination with hydrophobic ethyl cellulose (EC). Formulations prepared by the wet granulation technique and were evaluated for the release of TM over a period of 12 hours using United States Pharmacopoeia (USP) type-II dissolution apparatus. Along with physical properties, the dynamics of water uptake and erosion degree of tablets were also studied. The in-vitro drug release study revealed that formulation F3 (40% wt/wt HPMC K100M) could extend the drug release up to 8 hours. The most successful formulation of the study, F5 (HPMC to EC, 1:1), extended the drug release up to 12 hours, exhibited satisfactory drug release in the initial hours, and the total release pattern was close to the theoretical release profile. The drug release from optimized formulation (F5) followed first-order kinetics via Non-Fickian (anomalous) diffusion. FTIR studies revealed that there was no interaction between the drug and excipients. In conclusion, the results indicated that the prepared sustained-release tablets of TM could perform therapeutically better than conventional tablets with improved efficacy and better patient compliance.

 

Key words: Timolol maleate; Matrix tablets; Sustained-release; Ethyl cellulose; Hydroxypropylmethylcellulose; In-vitro drug release.


[PDF]  Viewed: 2496  Downloaded: 488
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter