Mon, 18 Dec 2017

A Review On Pharmacognostical, Phytochemical and Pharmacological Potentials of Kalanchoe pinnata (Crassulaceae)

Rajendra M. Kawade1*, Nitin B. ghiware1, Mahavir H. Ghante1, Shripad M. Malwatkar1, Sudhir M. Vadvalkar2, Avinash K. Dhadwe2, Rushikesh V. Choudhary1

1. Department of Pharmacology, Nanded Pharmacy College, Shyam nagar, Opp. Kasturba Matruseva Kendra, Nanded-431605, Maharashtra, India.

2.Nanded Pharmacy College (Poly), Shyam nagar, Opp. Kasturba Matruseva Kendra, Nanded-431605, Maharashtra, India.


ABSTRACT

Kalanchoe pinnata (Family: Crassulaceae) is an important plant which has many traditional medicinal uses. The main objective of this literature review was to give advance information for the drug discovery research for K. pinnata. It was found that this plant showed various pharmacological activities such as anthelmentic, immunosuppressive, wound healing, hepatoprotective, antinociceptive, anti-inflammatory, antidiabetic, nephroprotective, antioxidant activity, antimicrobial activity, analgesic, anticonvulsant, neuropharmacological and antipyretic. Anthelmentic activity was found due to the presence of tannins of the extract of K. pinnata and steroid glycosides such as bufadienolide showed wound healing activity. It was also found that the different flavonoids, polyphenols, triterpenoids and other chemical constituents of the plant were responsible for the antinociceptive, antiinflammatory and antidiabetic properties. Quercetin had a marked protective effect on cadmiuminduced nephrotoxicity and possessed potent oral efficacy against cutaneous leishmaniasis. The two new novel flavonoids such as 5Methyl 4, 5, 7 trihydroxyl flavone and 4, 3, 5, 7 tetrahydroxy 5-methyl 5 Ipropenamine anthocyanidines could be responsible for the antimicrobial activity of K. pinnata. Five bufadienolides (1-5) isolated from the leaves of K. pinnata were potential cancer chemopreventive agents. Quercitrin, a flavonoid, is a critical component of K. pinnata extract against an extreme allergic reaction. This literature review gave the evidence based information regarding the pharmacognostical, phytoconstituents and pharmacological activity of the medicinal plant, K. pinnata which could help researchers for more advanced qualitative research.

Keywords: Kalanchoe pinnata, Pharmacognostical, Phytochemical, Pharmacological


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