Mon, 18 Dec 2017

The Role of Glycogen Synthase Kinase(Gsk-3) In Pathophysiology of Diabetes Mellitus And Alzheimer’s Disease

Ajay D. Kshirsagar1, Haidarali M.Shaikh2*,Poonam Wadkar2, Sachin Mendhi2, Khatal Pravin2, Sadeque M. Shaikh 3

1. S.R.T.M. School of Pharmacy, Nanded-430106

2. Padmashree Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune- 411018

3. Shri Balaji Shikshan Prasarak Mamdal's , B.Pharmacy College, Ambajogai


ABSTRACT

Glycogen synthase kinase-3 (GSK-3) is an intermediary enzyme in various cellular pathways, and has been implicated in the Pathophysiology and treatment of numerous diseases, including Alzheimer, diabetes, and bipolar disorder. Alzheimer’s disease (AD) is a disorder without a molecular marker in peripheral tissues or a disease modifying treatment. Evidence suggest that the co-relation of diabetes and Alzheimer is clear with the GSK-3. Now day’s researchers taking efforts basically to develop the new GSK-3 inhibitors like lithium. For the development of new GSK-3 inhibitors, we have to understand its molecular mechanism and their involvement in pathological condition. So here we summarize brief introduction and mechanism of GSK-3.

Keywords: Glycogen synthase kinase-3 (GSK-3), Alzheimer’s disease, diabetes, bipolar disorder


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