DOI: 10.21276/ajptr
Fri, 21 Jun 2019

Newer Techniques to Enhance the Bioavailability of Hydrophobic Drugs by Means of Solubility Enhancement: A Review

Purushottam B. Malode 1*, Nikhilesh P. Karandikar1, Avinash B. Darekar1, Ravindra B. Saudagar1

1.Department of Pharmaceutics, R G Sapkal College of Pharmacy, Anjnery, Nashik-422213.


Enhancement of the solubility, dissolution and bioavailability of the drugs is the challenging task for the research sector. As many of the solubility enhancement techniques are available to achieve the desired goal, but the older techniques don’t show the expected results for solubility enhancement and bioavailability as well, and they are unstable also some time.  But today the scenario is different because the novel techniques of solubility enhancement are available, such as hydrotropy, supercritical fluid process, sonocrystallisation, inclusion complex system, spray drying, microwave assisted techniques, etc. this novel techniques have the ability to give the reproducible results for solubility enhancement in pharmaceutical product development.  present review article deals with the different techniques for the solubility enhancement of the poorly soluble drug candidates.

Keywords: Solubility, hydrophobic drugs, solubility enhancement, solid dispersion, beta cyclodextrin.


[PDF]   Viewed: 2161   Downloaded: 218
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.



  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.


  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.


web counter
web counter