Mon, 18 Dec 2017

Immediate Drug Release Dosage Form: A Review

Kiran Wale1*, Kishor Salunkhe2, Ishwar Gundecha2, Mahesh Balsane2, Snehal Hase2Priya Pande2. .

1.Amrutvahini College Of Pharmacy Sangamner,Ahmednagar,Maharashtra, India.


ABSTRACT

Over the past few decades, there has been an increased  interest for innovative drug delivery systems to improve safety, efficacy and patient compliance, thereby increasing the product patent life cycle. There are novel types of dosage forms that act very quickly after administration. The basic approach used in development tablets is the use of superdisintegrants like Cross linked carboxymelhyl cellulose (Croscarmeliose), Sodium starch glycolate (Primogel, Explotab), Polyvinylpyrrolidone (Polyplasdone) etc. which provide instantaneous disintegration of tablet after administration. Immediate release liquid dosage forms and parenteral dosage form have also been introduced for treating patients. Liquid dosage form can be suspensions with typical dispersion agents like hydroxypropyl methylcellulose, AOT (dioctylsulfosuccinate) etc. The development of immediate release therapy also provides an opportunity for a line extension in the marketplace, A wide range of drugs (e.g., neuroleptics, cardiovascular drugs, analgesics, antihistamines, and drugs can be considered candidates for this dosage form. In this regard, immediate release formulations are similar to many sustained release formulations that are now commonly available. oral film dosage form not only has certain advantages of other fast disintegrating systems but also satisfies the unmet needs of the market. The present review emphasizes on the potential benefits, design and development of robust, stable, and  innovative orally immediate and their future  scenarios on a global market as a pharmaceutical dosage form.

Keywords: Immediate release, polymers, superdisintegrant.


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