Mon, 18 Dec 2017

Similarities and Differences between different proton-pump inhibitor formulations for the treatment of gastro esophageal reflux disease A Review

Subrahmanyam PVRS1*, Chinna Reddy P1, Jithan Akunuru2 and Satyanarayana K3

1.Formulation R&D, Hetero Labs Ltd., Unit-III, Jeedimetla, Hyderabad-500055. India.

2.Mother Theresa College of Pharmacy, Hyderabad, A.P., India.

3.Princeton college of Pharmacy, Hyderabad, A.P., India.


ABSTRACT

Gastro esophageal reflux disease is a chronic, recurrent disease that affects millions of people worldwide. Proton pump inhibitors are a group of drugs whose main action is a pronounced and long-lasting reduction of gastric acid production. These drugs are utilized in the treatment of many conditions such as Dyspepsia, Peptic ulcer disease, Gastro esophageal reflux disease. Currently proton pump inhibitors are available in both oral and injectable formulation. Proton pump inhibitors are substituted benzimidazoles that inhibit gastric acid secretion via inhibition of the gastric H+/K+ ATPase pump. Although there are some differences in pharmacokinetics and binding affinity for the pump, these drugs are comparatively similar in their efficacy in treatment of gastric diseases. The delayed release proton pump inhibitors effectively suppress gastric acid secretion and successfully treat acid-related disorders. Each differs somewhat in its formulations. The difference in the formulations has not been translated  into clinical advantages over the delayed release proton pump inhibitors. Novel multiple formulations approaches are required for proton pump inhibitors to enhance acid suppression. Although the individual proton pump inhibitors have similar efficacy in many cases, differences between them should be considered when choosing a treatment regimen.

Keyword: Gastro esophageal reflux disease, Proton pump inhibitors, Pharmacokinetics


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