DOI: 10.21276/ajptr
Fri, 21 Jun 2019

Synthesis and Antibacterial Activity of Substituted 2-Quinolones

Noor Fathima Anjum*1, Jagarlamudi Leela Rani2 , Abdul Aleem3, Sukhen Som4 , Mohammed Saif ulla khan4

1. Krupanidhi College of Pharmacy1. Bangalore-560035, Karnataka. India

2. Bapatla College of pharmacy, Guntur Dist 522101, Andhra Pradesh. India

3. Al-Ameen College of Pharmacy, Bangalore- -560027, Karnataka. India

4. M.M.U College of Pharmacy. K.K.Doddi, Ramanagara- 562159, Karnataka. India


Quinolines are a class of heterocyclic compounds, widely present in nature as quinoline alkaloids. Compounds having 2-quinolone moiety are associated with interesting biological activities such as antimalarial, tuberculostatic, antibacterial, antiviral, antifungal, anticancer, antidiabetic, cardiotonic and bronchodilator activity etc. The present work deals with the synthesis, characterization of substituted 7-amino-4-methyl-2-quinolone. The synthesized compounds were characterized by the IR, 1H-NMR & Mass spectral studies. Out of 10 test compounds evaluated for their antibacterial activities, four test compounds 3,6,8 & 9 were found to be active against Bacillus subtilis while amoxycillin and gentamycin were used as standard.

Keywords: 2-quinolone; Schiff bases, antibacterial activity.

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