Mon, 18 Dec 2017

Phytochemical Screening and Ulcer Protective Activity of Ethanolic Seeds Extract of Gynocardia odorata In Different Ulcer Model

Shrish Kumar Srivastava*1, Hemant kumar2, Mrityunjoy Acharya 3

1.Doon College of Education (Department of Pharmacy), NH-27A, Delhi-Dehradun Road, Sunderpur, Saharanpur- 247662.UP, India.

2. Saroj Institute of Technology and Management, Ahimamau, Lucknow - 226001, U.P, India

3.GRD (PG) IMT (Department of Pharmacy), 214-Rajpur Road Dehradun-248009. Uttarakhand, India.


ABSTRACT

Peptic ulcer is the areas of degeneration and necrosis of gastrointestinal mucosa exposed to acid peptic secretion. Some other factors, such as inadequate dietary habits, excessive ingestion of non-steroidal anti-inflammatory agents, stress, hereditary predisposition and infection by Helicobacter pylori, may be responsible for the development of peptic ulcer. The several herbal formulations derived from Ayurveda and its additional systems of medicine, not yet to be scientifically validated that they have exhibited anti-ulcer activity. Our present study was to evaluate the ulcer protective activity of ethanolic extract of Gynocardia odorata (G.   ordata) seeds on cold restraint and ethanol induced ulcer model. Five groups were taken (n=6). First groups serve as negative control (Without any treatment). Second groups were treated with vehicles only. Third groups were treated with some standard marketed drugs (Ranitidine and sucralfate). Fourth and fifth groups were treated with ethanolic seed extract of G. odorata in two increasing dose (250 and 500mg/kg body weight p.o respectively). Both the group showed significant ulcer protective activity in a dose dependent manner.

Keywords: Gynocardia odorata, Cold restrain ulcer, Ethanol induced ulcer, Flavonoids. Ulcer  protective.


[PDF]  Viewed: 735  Downloaded: 112
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter