DOI: 10.21276/ajptr
Fri, 19 Apr 2019

Formulation and Evaluation of Gastroretentive Floating Tablets of an Antipsychotic Drug

Srilakshmi P1, Kranthi Koushik N1, Shalem Raju D1, Rama Rao N1, Lakshmi Prasanna J1*, Deepthi B1

1.Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur.


The present study was carried out in fabricating gastro retentive formulation of an antipsychotic drug using semi synthetic and natural polymers. Floating tablets were prepared by direct compression method using directly compressible microcrystalline cellulose as vehicle. Gum Xanthan and hydroxypropyl methylcellulose (HPMC E4M) were used as polymers for sustaining the drug release and sodium bicarbonate was used as an effervescent agent. Tablets were characterized for their pre compression and post compression parameters. Floating characteristics like floating lag time, floating time were evaluated and were considered as one of the factor for selecting the best formulation. The in vitro release studies were carried out in pH 1.2 buffer for 8hrs. The content uniformity was found to be within the compendial requirements and the release was extended for more than 8hrs. The best fit release kinetics was achieved with zero order followed by higuchi and non-fickian diffusion. The release of Quetiapine fumarate was significantly influenced by the concentration of polymer.

Keywords: Gastro retentive floating tablet, HPMC, Quetiapine fumarate, Xanthan gum

[PDF]   Viewed: 2688   Downloaded: 366
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.



  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.


  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.


web counter
web counter