Mon, 18 Dec 2017

Formulation and Evaluation of Wound Remodeling Potential of Dual Herbal Ointment

Abdul Aleem1, Noor Fathima Anjum*2, Mohammed Saif Ulla Khan3

1.Department of Pharmaceutics. Al-Ameen College of Pharmacy1, Bangalore- -560027, Karnataka. India

2.Department of Pharmaceutical Chemistry. Krupanidhi College of Pharmacy2. Bangalore-560035, Karnataka. India

3.Department of Pharmaceutical Chemistry. M.M.U College of Pharmacy3. K.K.Doddi, Ramanagara- 562159, Karnataka. India


ABSTRACT

The present study was aimed at formulating and evaluating a herbal ointment comprising of Ethanolic extracts of the parts of morindacitrifolia, and rubiacordifolia. The parameters evaluated for wound healing were period of contraction and tensile strength using excision and incision models. The animals were divided into groups and were treated with herbal formulation, standard group and one served as control group.  Nitrofurazone (0.2% w/w) was used as reference standard. The period of epithelization in the excision wound mode was found to be 13.20 days, while in case of incision wound model the tensile strength was 540 when compared to the controls ,the results were  extremely significant. Different parameters like pH, viscosity, Spreadability and stability were evaluated. The formulation showed good spread ability, good consistency, homogeneity, there was no change in the appearance, pH, and no phase separation noticed at the end of the stability studies. There was no evidence of skin irritation. This study has revealed that the herbal ointment has shown the wound healing effect due to the synergistic activity of the phytoconstituents present in the extracts and may be used as potential herbal formulation for wound healing.

Keywords: morindacitrifolia, rubiacordifolia, Ethanolic extract, wound healing.


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