DOI: 10.21276/ajptr
Fri, 21 Jun 2019

Eco-Friendly Synthesis and Antimicrobial Activity of N-[7-(5-Substitutedimino-3-Amino)-1,2,4-Dithiazo-4-Yl]-N,N-Diethyl-Pentane-1,4-Diamine

A.K. Wanjari

1.Department of Chemistry, Mahatma Fule Arts, Commerce & Sitaramji Chaudhari Science  Mahavidyalaya Warud, Dist.:-Amravati (M.S.). Pin code 444906, India.


Heteroacyclic and Heterocyclic containing drugs showed remarkable and noticeable drug absorption, transmission and drug effects; hence they created their own identity and importance in pharmaceutical, medicinal, agricultural and drug sciences. Benzonido and pyridino, dithiazolo, quinolino and alkylamino heterocycles showed important applications in industrial, pharmaceutical, medicinal and drug chemistry.  Considering all these facts into consideration recently in this laboratory interaction of N-(7-chloroquinoline-4-yl)-N,N-diethyl-pentane-1,4-diamine (1) was carried out with thiourea (2) in ethanol medium to isolate N-(7-thiocarbamidoquinoline-4-yl)-N,N-diethyl-pentane-1,4-diamines (3). N-(7-thiocarbamido quinoline-4-yl)-N,N-diethyl-pentane-1,4-diamines on further interactions with various isothiocynates (4) in acetone-ethanol medium produces N-[7-(1- substituted) -2,4-dithiobiureto)-4-yl]-N,N-diethyl-pentane-1,4-diamine (5) which were successfully  oxidatively cyclised into N-[7-(5-substitutedimino-3-amino)-1,2,4-dithiazo-4-yl]-N,N-diethyl-pentane-1,4-diamine (6) these reactions are hither to unknown. The justification and identification of the structure of these newly synthesized compounds had been established on the basis of chemical characterization, elemental analysis and through spectral data.

Keywords: Substituted isothiocynates, N-(7-substitutedthiocarbamidoquinoline-4-yl)-N,N-diethyl-pentane-1,4-diamines, Green synthesis, bromine, acetone, ethanol and carbon tetrachloride.

[PDF]   Viewed: 1234   Downloaded: 121
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.



  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.


  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.


web counter
web counter