Mon, 18 Dec 2017

Effect of Meloxicam on the Phrmacokinetics of Pefloxacin and Its Active Metabolite Norfloxacin in Female Goats

Nitesh Kumar*1, Challapa Jayachandran2

1. Head, Department of Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, Rewa – 486 001, India

2. Ex-University Professor and Chairman, Department of Pharmacology and Toxicology, Bihar Veterinary College, Patna 800 014, India


ABSTRACT

A study on pharmacokinetics of pefloxacin and kinetic interaction between pefloxacin (5 mg/kg) and meloxicam (0.5 mg/kg) was carried out through intravenous route in 5 female goats weighing 18-22 kg. A wash out period of 3 weeks was used before each injection. Blood (0.042-48 h) and urine (0.042-72 h) samples were collected. Estimation of pefloxacin and its active metabolite norfloxacin were carried out by using High Performance Liquid chromatography (HPLC). Shorter distribution half life (t1/2 α) of 0.16 h and elimination half life (t1/2 β) of 2.42 h were noted in pefloxacin alone administration and non-significant differences were noted in combination with meloxicam.  Significantly (P<0.05) longer t1/2 β was obtained for norfloxacin in combined administration as compared to alone administration of pefloxacin. Significantly (P<0.05) lower total body clearance (ClB) of 5.92 ml/kg/min was obtained for norfloxacin in combined administration as compared to alone administration (16.62 ml/kg/min). Significantly (P<0.05) higher Vdarea of 0.98 L/kg was obtained in combined administration as compared to alone administration (Vdarea = 0.76 L/kg). This may be the reason that significantly (P<0.05) higher approximate tissue to plasma concentration ratio (T P) of 8.56 was noted for pefloxaxcin in combined administration as compared to alone administration (3.95). Significantly (P<0.05) higher % conversion of pefloxacin to norfloxacin (60.70) was noted in combined administration as compared to alone administration (22.34). Further, the calculated dosage regimen for maintaining minimum therapeutic concentration was found to be significantly (P<0.05) lower in combination as compared to alone administration.

Keywords: - Kinetics, Pefloxacin, Meloxicam, Goats


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