DOI: 10.21276/ajptr
Thu, 20 Jun 2019

Visible Spectrophotometric Method for Estimation of Lurasidone Hydrochloride In Synthetic Mixture

Satish A Patel1, Krunal Y Patel1*.

1. Department of Pharmaceutical Quality Assurance, Shree S. K. Patel College of Pharmaceutical Education & Research, Ganpat University, Kherva – 382711, Mehsana, Gujarat, India.


A simple, sensitive, accurate, precise and economical visible spectrophotometric method was developed and validated for the estimation of lurasidone Hydrochloride in synthetic mixture. The method is based on the reaction of lurasidone Hydrochloride with bromocresol green dye in dichloromethane giving yellow color chromogen, which shows maximum absorbance at 418 nm against reagent blank. The chromogen obeyed Beer’s law in the concentration range of 4-12 µg/ml for lurasidone Hydrochloride. The results of the analysis have been validated statistically and by recovery studies.

Keywords: Lurasidone Hydrochloride, Chromogen, Bromocresol green, Visible spectrophotometric.

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