Mon, 18 Dec 2017

Chemopreventive and Chemotherapeutic Role of Taurine Against 7,12-Dimethylbenze(A)Anthracene Induced Mammary Carcinoma In Experimental Female Sprague-Dawley Rats

Vanitha Kalappan1*, Dhanapal Sakthisekaran1, Aruldass Ilakkia1, Kuppusamy Periyasamy1, Kuppusamy Basker1, Sundaramoorthy Selvaraj1,

1. Department of Medical Biochemistry, University of Madras, Chennai-600113


ABSTRACT

Breast cancer is one of the most serious problems in oncology. It is a leading cause of death among women in many countries. Environmental factors, of either biological or chemical origin, may act as initiators and promoters of  the carcinogenesis. Chemical carcinogens such as 7,12-dimethylbenz[a] anthracene [DMBA],benz[a]pyrene [BP], and N-nitroso-N-methylurea are commonly employed to initiate and promote neoplastic transformation in experimental animals. DMBA is well established as a highly potent carcinogen. Cancer chemoprevention is recognized as the most promising and novel approach to prevent, inhibit or reverse the carcinogenic processes by intervention with natural products or synthetic chemical substances. Taurine is a sulfur containing beta amino acid with a wide range of vital, biological functions, ranging modulation, cell membrane stabilization to bearing an antioxidant and scavenging agent. In from neuro the last decade it has been widely used in the field of oncology as a chemo protective agent against hepatocarcinogenesis and colon carcinogenesis. The aim of this study was to get insight into the process of chemo resistance acquisition for a better understanding of the breast cancer therapy. Therefore, the current study has been undertaken to examine the effect of taurine on DMBA induced breast cancer in rats. At the end of the experimental period, the homogenized breast tissue was investigated and recorded the body weight, tumor weight and antitumor activity of Taurine in the experimental rats. Overall, these results suggested that the taurine treatment provided antioxidant defense with strong chemopreventive activity against the genesis of DMBA-induced mammary carcinoma.


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