Mon, 18 Dec 2017

Investigation of Flavones as Efficient anti–oxidant and anti-inflammatory Agents

Rajashree A. Markandewar*1, M. H.Ghante2, M. A. Baseer3.

1Department of Applied Chemistry, Ballarpur Institute of Technology, Ballarpur-442701.

2Department of Pharmacognosy, Nanded Pharmacy College, Nanded-431601

3Department of Chemistry, Yeshwant Mahavidyalaya, Nanded-431601


ABSTRACT

Flavones, have been synthesized by the oxidative cyclization of 2'-hydroxychalcones using catalytic amount of iodine in presence of dimethyl sulfoxide (DMSO) in maximum yield. The synthesized compounds were evaluated for anti-oxidant and anti-inflammatory potential. Two compounds showed good anti-inflammatory activity as compared to their antioxidant activities. The synthesized compounds were characterized by IR, 1HNMR and MS Spectroscopy.

Keywords: Flavones, anti-oxidant, anti-inflammatory, oxidative-cyclization, DMSO.


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