Mon, 18 Dec 2017

Xyloglucan Calcium Alginate (Ca) Coated Microbeads of Aceclofenac Sodium For Oral Controlled Drug Delivery

K.M. Manjanna1*, B. Shivakumar2,  K. S. Rajesh3

1.Department of pharmaceutics, T.V.M.College of pharmacy, Bellary Karnataka, India

2.Department of pharmaceutical chemistry. B.L.D.E College of pharmacy. Bijapur Karnataka, India.

3.Department of pharmaceutics, Parul institute of pharmacy, Limda, Gujarat, India .


ABSTRACT

The aceclofenac sodium loaded calcium alginate (CA) based microbeads prepared by ionotropic external gelation technique with calcium chloride as cross-linking agent. Calcium alginate microbeads represent a useful tool for oral sustained/ controlled drug delivery but show several problems, mainly related to the stability, and rapid drug release at higher pH that, in most cases, is too fast due to increase porosity. To overcome such inconveniences, which was to develop CA microbeads coated with xyloglucan (XG) as drug release modifier to improve stability and prolong the drug release. The mean particle sizes of drug-loaded microbeads were found to be in the range 476.45±12 to 765.10 ± 0.22. The drug entrapment efficiency was obtained in the range of 62.24±0.66 to 102.75 ± 0.87.The shape and surface characteristics were determined by scanning electron microscopy (SEM). No significant drug-polymer interactions, physical changes and crystallinity of the drug in the formulations were determined by FT-IR spectroscopy, differential scanning calorimetry (DSC) and X-ray powder diffraction [XPRD]. In-vitro drug release profiles of microbeads were pH dependent and were analyzed by different kinetic models. The mechanism of drug release from microbeads depends on swelling and erosion process resulting CA microbeads was diffusion controlled followed by First order kinetics and whereas CA microbeads coated with XG approaching to near Zero- order kinetics.

Keywords: Sodium alginate, Xyloglucan aceclofenac sodium, Oral bioavailability, Natural hydrogels, pH dependent, Zero-order kinetics


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