DOI: 10.21276/ajptr
Fri, 21 Jun 2019

Formulation and Evaluation of Bilayered Tablets of Anti-Platelet Drugs

Krishna R. Raparla1, YA Chowdary*2  Sushma P1

1.Department of  Pharmaceutics, Vaageswari Institute of Pharmaceutical Sciences, Beside LMD police station, Karimnagar, Andhrapradesh, India – 505481

2.Department of  Pharmaceutics, NRI College Of Pharmacy, Pothavarapadu village, Via Nunna, Agiripalli Mandal, Krishna Dist, Andhrapradesh, India – 521 212


A series of chalcones was synthesized by the Claisen-Schmidt condensation and the structures of 1-(4-bromophenyl)-3-phenylprop-2-en-1-ones were established with the help of IR and NMR study, then their effect was observed on bovine serum albumin. We have found that the synthesized chalcones interacted with bovine serum albumin irrespective of position and nature of substituent. 1-(4-bromophenyl)-3-(3-methoxyphenyl)-prop-2-en-1-one has been found to interact with BSA maximally.

Keywords: Bovine serum albumin, interaction studies, chalcones of p-bromoacetophenone.

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