DOI: 10.21276/ajptr
Fri, 19 Apr 2019

Synthesis, characterization and antimicrobial activity of novel 5-substituted aryl-2,7-diphenyl-1,3,4-thiadiazolo-[3,2-a]-1,3,5-triazine derivatives

Deepak Kumar Basedia*1, Birendra Shrivastava1, B. K. Dubey2, Pankaj Sharma1

1. School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India.

2. T.I.T. College of  Pharmacy, Anand Nagar, BHEL, Bhopal, M.P., India.


A new class of heterocyclic compounds 1,3,4-thiadiazolo[3,2-a]-s-triazine have been synthesized as schiff’s base of 1,3,4- thiadiazole mix with ammonium acetate and various aromatic aldehyde treated in MW irradiation at 480 W. Reaction is based on microwave mediate multi-component reaction (MCRs). The structures of these compounds have been elucidated by spectral (IR, NMR & Mass) analysis. The title compounds were then evaluated for their in-vitro microbial activity against 2 gram –Ve bacteria (E.coli, K. pneumoniae), 2 gram +Ve bacteria (S.aerues, B.subtilis) and 1 fungal specie (A.niger). The some newly synthesized compounds have shown promising antimicrobial activity.

Keywords: 1,3,5-Triazine, 1,3,4-Thiadiazole, Thiosemicarbazone, Schiff’s base, Antibacterial, Antifungal,  Multi-component reaction (MCRs)

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