Mon, 18 Dec 2017

Synthesis, Antibacterial Activity and Preliminary QSAR Studies of Diaryl Sulfones

Ashwini Wani*1, Supriya Mahajan2

1.Vivekanand Education Society’s College of Pharmacy, Chembur, Mumbai-400074, India.

2.C. U. Shah College of Pharmacy, S. N. D. T. Women’s University, Santacruz (W), Mumbai-400049, India


ABSTRACT

Sulfones are known to possess various biological activities. Their great potential as bioactive compounds, combined with the easy method of synthesis, make this class a strong candidate for the production of medicines economically. This article deals with the synthesis of a series of ten diaryl sulfones, their antibacterial activity, individually, synergistic antibacterial activity with trimethoprim against E. coli and preliminary QSAR studies. The antibacterial activity was performed by agar diffusion method, against Gram positive and Gram negative bacteria. Few derivatives exhibited antibacterial activity comparable to or better than the standard, sulphamethoxazole, against Gram negative organisms (E. coli and S. dysentrae). Sulfones being folic acid inhibitors, their synergistic effect was checked with trimethoprim on E. coli. Most of the compounds exhibited synergistic effect with trimethoprim, which was better than the combination of trimethoprim and sulfamethoxazole (1:5). Quantitative structure activity relationships studies were performed by multiple linear regression analysis. The antibacterial activity of sulfones was found to correlate well with their dipole moment and ionization potential.

Keywords: Diaryl sulfones, Antimicrobial activity, Synergistic effect, QSAR


[PDF]  Viewed: 918  Downloaded: 141
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter