Thu, 14 Dec 2017

SPECTROFLUORIMETRIC DETERMINATION OF CELECOXIB IN BULK AND FORMULATIONS

Sunil Kumar Dubey*1, Chiranjeevi Venkatesh K1, Jangala Hemanth1

 

1. Department of Pharmacy, Birla Institute of Technology & Science, Pilani-333031, India


ABSTRACT

 

A simple, rapid and economical spectrofluorimetric method for estimation of Celecoxib, a selective COX-2 inhibitor, in bulk and solid dosage forms was developed in the present study. Celecoxib shows maximum excitation intensity at 245 nm and maximum emission intensity at 382 nm which is used in this study. The linear regression equation obtained by least square regression method, was Int =0.253*Conc. (in ng/ml) +34.80. The method provides a linear response across a quantization range of 250ng/ml to 4000ng/ml. The developed method was employed with a high degree of precision and accuracy for the estimation of total drug content in three commercial capsule formulations of Celecoxib. The results of analysis were treated statistically, as per International Conference on Harmonisation (ICH) guidelines for validation of analytical procedures. The results were found to be accurate, reproducible and free from interference.

 

Keywords: Celecoxib; Spectrofluorimeter; Recovery Studies


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