DOI: 10.21276/ajptr
Tue, 21 May 2019

A Brief Insight into Rational and Novel Approaches to Ocular Drug Delivery

Mansi Shah*1, Sanket Shah1, Y. K. Agarwal1


1. Department of Research & Development, Gujarat Forensic Sciences University, Gandhinagar, Gujarat, India-382007

As an isolated organ, eye is very difficult to study from a drug delivery point of view. Ophthalmic drug delivery is extremely interesting and highly challenging endeavours. In recent scenario, most eye-diseases are treated with topical application of eye-drops. But these conventional eye-drops have two major problems. 1) It needs frequent administration at every 4 hours or 1 hour if the infection is severe and 2) Formation of crystalline deposits on cornea due to its pH-dependent solubility which is very low. In order to provide the solution to above problems many new formulations have been developed, which include nanosuspension, nanoemulsion, inserts, hydrogels, in-situ gel, etc. The poor bioavailability of ophthalmic solution caused by dilution and drainage from the eye can be overcome by using in-situ forming ophthalmic drug delivery system prepared from polymers that exhibit reversible liquid-gel phase transition. The developed formulation provides better drug product effectiveness, reliability, stability, safety, non-irritancy and prolonged release. Thus, it’s a viable alternative to conventional eye-drops by virtue of its ability to enhance bioavailability through its longer pre-corneal residence time & ability to provide prolonged drug release upto 8 hours. The main important factor is the reduced frequency & the ease of installation resulting in better patient acceptance.

Keywords: Ophthalmic delivery, in-situ gel, polymers, liquid-gel phase transition, pre-corneal residence time, prolonged drug release.

[PDF]   Viewed: 1839   Downloaded: 251
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.



  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.


  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.


web counter
web counter