DOI: 10.21276/ajptr
Tue, 21 May 2019

Potentials of Inclusion Complex with special Reference to Cyclodextrin

U. K. Patil1* , Ranju Pal2, Kundlik Girhepunje1


1. Peoples College of Pharmacy and Research Centre, Bhanpur, Bhopal, (M.P.)

2. Department of Pharmacy, Barkatullah University, Bhopal (M.P.)

Cyclodextrins, the unique cyclic carbohydrates are successfully utilized as the potential complexing agents which form inclusion complex with insoluble drugs. “Inclusion complex”, this term refers to the dispersion of one or more actives ingredients in an inert carrier or matrix at molecular state. Now a day several drugs molecules are being introduced and many newer techniques have been developed for the formulation of dosage forms but when these drug molecules become more and more complex, sophistication has to find its way in the area of excipients, which are needed to formulate these drug substances optimally. One such versatile adjuvant, tailored with the help of advances in biotechnology and enzyme technology is cyclodextrin. Cyclodextrin are cyclic oligosaccharides which have been recognized as useful pharmaceutical excipients. The molecular structure of these glucose derivatives generates a hydrophilic exterior surface and a non polar cavity interior. Such cyclodextrin can interact with appropriate size drug molecules which lead to the formation of inclusion complexes. A comprehensive literature survey was made collect the rightful utilization of cyclodextrins as complexing, solubility enhancing agents and permeation enhancers.

Key words: Inclusion complexes, Cyclodextrins, Excipients, Complexing agent, Hydrophilic exterior surface

[PDF]   Viewed: 1530   Downloaded: 108
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.



  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.


  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.


web counter
web counter