Tue, 21 Nov 2017

Synthesis and antimicrobial activity of 2-(1h-benzimidazol -2- ylsulfanyl)-n-phenylacetamide

 

Mohammed Waseem*, Mohammad Saqib, Kishore Singh Chatrapati, H. J. Kallur, Somnath D. Bhinge, Mohammad Anwar Hussain1

 

1. Department of Pharmachemistry, RMES’s College of Pharmacy Gulbarga - 585 102

2. Department of Pharmachemistry, SJM College of Pharmacy Chitradurga  577502, Karnataka


 

In the present study, a series of substituted 2-(1H-benzimidazol-2-ylsulfanyl)-N-phenylacetamide was prepared. The synthesis of titled compounds from starting material unsubstituted 2-mercapto benzimidazoles was prepared from o-phenylenediamine and carbon disulfide in presence of KOH in single step. 2-mercapto Benzimidazole on reacting with N-substituted-α-chloroacetanilides yield different derivatives of Benzimidazole. The structure of new compounds  prepared  during  present  investigation  have  been authentically established by their IR,1H NMR and Mass spectral studies. The antibacterial and antifungal activities of thiadiazole derivatives also reported. Some of these derivatives exhibit significant antimicrobial activity.

Key words: 2-mercapto benzimidazoles, phenylacetamide, antibacterial, antifungal.


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