Tue, 21 Nov 2017

Stability indicating GC-FID method for estimation of Camylofin dihydrochloride and Paracetamol in pharmaceutical dosage form

 

RajeevKumar R. Singh*, Manapragada V. Rathnam

 

1. Department of Chemistry. B.N. Bandodkar College of Science, Chendani, Thane-400 601, Maharashtra, (INDIA)


 

This research paper describes simple analytical method for determination of Camylofin dihydrochloride and Paracetamol in syrup formulation by Gas chromatography method. Benzoic acid was used as internal standard. Validation was carried out in compliance with the International Conference on Harmonization guidelines. The method utilized GC (Agilent Technologies 6890N Network GC system with FID detector), and RTX-5 capillary column (Crossbond 50% diphenyl-95% dimethyl polysiloxane), 30m x 0.53mm, 1.5µm as stationary phase. Helium was used as the carrier gas.  The proposed method was validated for linearity, LOD, LOQ, accuracy, precision, ruggedness and solution stability. It can be conveniently adopted for routine quality control analysis.

Key Words:Validation, Gas chromatography, Pharmaceutical preparations, Camylofin dihydrochloride, Paracetamol.


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