DOI: 10.21276/ajptr
Tue, 21 May 2019

Development and Validation of UV Spectroscopy method for Estimation of Ranalozine in bulk and its Pharmaceutical Formulation


Ramanaiah Ganji *, D. Ramachandran, G Srinivas, Jayapal Gowardhane, Purnachanda Rao


1. Department of Chemistry, Acharya Nagarjuna University Nuzivid campus, Andhra Pradesh, India.


A rapid and sensitive UV-Visible spectroscopic method was developed for the estimation of Ranalozine in pure and its Pharmaceutical formulations. The method was validated as per International Conference on Harmonization [ICH] guidelines. The Ranalozine was monitored at 230nm with UV detection and there is interference of diluent at 230nm for Ranalozine. The method was linear (r2 =0.999) at concentration ranging from 12 to 40μg/ml, precise (intra-day relative standard deviation [RSD] and inter-day RSD values < 1.0%), accurate (mean recovery = 100.2%), specific and robust. The results showed that the proposed method is suitable for the precise, accurate and rapid determination of Ranalozine in bulk, its capsule dosage forms.

Key Words: Ranalozine, UV-Visible spectroscopy, Validation, Dosage form.

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