Sat, 18 Nov 2017

Formulation and evaluation of mucoadhesive buccal patches of Tramadol hydrochloride

 

R. Yogananda *1, Rakesh Bulugondla1, T.S. Nagaraja1, Snehalatha1, LakshmiRadhika .G1.

1. Department of Pharmaceutics, S.J.M College of Pharmacy, Chitradurga-577502, Karnataka, India.

 


 

The goal of present investigation highlights the formulation and evaluation of mucoadhesive buccal patches of Tramadol hydrochloride. The mucoadhesive buccal patches of Tramadol hydrochloride were prepared by solvent casting technique using various concentrations of Chitosan polymer. The formulated patches were evaluated for their physicochemical parameters like thickness, weight variation, surface pH, content uniformity, folding endurance swelling percentage studies and in vitro residence time. In vitro release studies were performed with pH 6.8 phosphate buffer solution. Good results were obtained both in physicochemical and in vitro studies. The films were exhibited controlled release more than six hours. The in-vitro release datas were fit to different equation and kinetic models to explain release profiles. The best mucoadhesive performance and matrix controlled release was exhibited by the formulation R6. The formulation was found be right and suitable candidate for the formulation of Tramadol HCL mucoadhesive buccal patches for therapeutic use.

Key words: Tramadol HCL, Chitosan, Mucoadhesive buccal patches, PVP K-30.


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