Sat, 18 Nov 2017

Design and In-Vitro evaluation of human serum albumin loaded Paclitaxel nanosuspension

 

AmarnathReddy Ganji1,*, Kiran K Jadhav1, Sanjay P Umachigi1, Pradeep Shivakumar1, Palleti SainathReddy1, Yedla Anilchowdary2

 

1. Gautham College of Pharmacy, Department of Pharmaceutics, Bangalore, India.

2. Lamar University, Department of Chemistry, Beaumont, Texas, U.S.A.


 

ABSTRACT

At current 40% of the drugs were poorly soluble and were also called as “brick dust”. And the drugs which were belonging to the BCS CLASS II & IV were most eligible for this Nanosuspension technology. Here by using different methods we are reducing the particle size so the surface area will be increases ultimately it leads to increase in the bio availability. This instance was observed mostly in the case of anti-cancer drugs. Paclitaxel with 25% of Human Serum Albumin (HSA) showed very good results in terms of drug content, particle size, zeta potential and %CDR.

Key words: Nanosuspension, Paclitaxel, Human Serum Albumin (HSA), High pressure homogenization.


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