DOI: 10.21276/ajptr
Fri, 24 May 2019

Effect of Purified Lycopene on Lipid Profile, Antioxidant Enzyme and Blood Glucose In Hyperlipidemic Rabbits


Sarita A. Mulkalwar*1, Niranjan S. Munjal1, U.K. More1, Balaji More1, Amol B. Chaudhari1, Pavitra Raj Dewda1


1. Pd.Dr.D.Y.Patil Medical College,Hospital and Research Centre, Pimpri, Pune-411018.



While tomato products supplementation, containing various carotenoids, including lycopene has hypolipidemic and antioxidant effect, the role of purified lycopene for the same remains unclear. Thus we tested the effect of pure lycopene powder for its effect on lipid profile, blood glucose and antioxidant enzyme in hyperlipidemic rabbits.Male New- Zealand White rabbits were used. Blood samples from all the 12 rabbits were taken for the baseline level of lipids, [Serum Total Cholesterol (TC), Low Density Lipoproteins (LDL), Serum Triglycerides (TG), High Density Lipoproteins (HDL)] blood glucose and blood superoxide dismutase(SOD). Same tests were performed in high fat diet fed (control group) and high fat diet + lycopene (10 mg/kg) (test group) after 6 weeks. There was a significant decrease in the level of serum TC, LDL – C and serum TG and an increase in serum HDL – C and antioxidant SOD after addition of lycopene to high fat diet. There was however no change in blood glucose level. Purified lycopene showed significant hypolipidemic and antioxidant activity. However, it did not show significant effect on blood glucose level.

Key Words: Lycopene, Hypolipidemia, Antioxidant Superoxide Dismutase, High fat diet.

[PDF]   Viewed: 2418   Downloaded: 241
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.



  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.


  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.


web counter
web counter