DOI: 10.21276/ajptr
Tue, 21 May 2019

Extended Release Formulation of Metoprolol Succinate Using Ion Exchange Technology



Sneha V. Sawant1, Shirish V. Sankpal1, Kisan R. Jadhav1, Vilasrao J. Kadam1Meenakshi Chandra*1


1.    The Department of Pharmaceutics, Bharati Vidyapeeth’s College of Pharmacy, CBD Belapur, Sector-8, Navi-Mumbai-400614, India




The purpose of this research work was to prepare an extended release formulation of metoprolol succinate using Ion exchange resin. Metoprolol succinate has short half life of 3-7 hours. So it needs to be administered 3-4 times a day. Hence an extended release preparation is desired. Drug-resin complex (DRC) was obtained by loading metoprolol succinate onto a strong cation exchange resin, Indion 244 in the ratio 1.5:1 using batch method. The molecular properties of the complex were investigated by differential scanning calorimetry, X-ray powder diffraction and Infra red spectroscopy which revealed interaction of drug with resin. To achieve the desired release rate, the DRC was initially treated with an impregnating agent, polyethylene glycol (PEG) 4000 and was further treated with hydrophobic polymer ethyl cellulose. Various formulations of tablets using resinate were prepared to achieve desired drug release profile. The formulations were evaluated for hardness, friability, weight variation, in vitro release and assay using HPLC. Formulation (V) shows optimum results in terms of release profile, which were in accordance with the USP specifications. The in vitro release profile showed that complexation of drug with ion exchange resin and use of hydrophobic polymer matrix could retard the initial burst and extend the release of drug up to 24 hours.

Keywords: metoprolol succinate, Indion 244, drug-resin complex, PEG 4000, ethyl cellulose

[PDF]   Viewed: 4387   Downloaded: 556
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.



  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.


  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.


web counter
web counter