DOI: 10.21276/ajptr
Sat, 25 May 2019

In-Situ Gelling System: A Novel Approach for Ocular Drug Delivery


Gourav Rajoria*, Arushi Gupta


1 Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab, 142001 India




Eye, which is the most vital organ of the body suffer from various eye problems like glaucoma, endopthalmitis, dry eye syndrome, trachoma, keratitis, conjunctivitis etc. Most ocular diseases are treated by topical drug application in the form of solutions, suspensions and ointment. These conventional dosage forms suffer from the problems of poor ocular bioavailability because of dilution and rapid drainage. Prolonged drug delivery can be achieved  by various new dosage forms like in-situ gel, collagen shield, minidisc, ocular film, ocusert, nanosuspension, nanoparticulate system, liposomes, niosomes, dendrimers, ocular iontophoresis etc. The most successful of these is the in-situ forming ophthalmic drug delivery systems prepared from polymers that exhibit reversible liquid-gel phase transition .The aim of this article is to present a concise review of in-situ gelling system to overcome all above problems. This review also summarizes various temperature, pH, and ion induced in-situ forming polymeric systems used to achieve prolonged contact time of drugs with the cornea and increase their bioavailability.

Keywords:  Ophthalmic Solution, In-Situ, Hydrogel, Liquid-gel transition.

[PDF]   Viewed: 3704   Downloaded: 778
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.



  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.


  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.


web counter
web counter