Mon, 20 Nov 2017

Development and Validation of UV Spectrophotometric Method for Determination of Cefuroxime in Pharmaceutical Dosage forms

 

Md Rezowanur Rahman1, Md. Asaduzzaman2, S.M. Ashraful Islam2*

1. Department of Pharmaceutical Technology, University of Dhaka, Dhaka-1000, Bangladesh

2. Department of Pharmacy, University of Asia Pacific, Dhanmondi, Dhaka-1209,Bangladesh


 

ABSTRACT

 

A rapid and sensitive UV-Visible spectroscopic method was developed for the estimation of cefuroxime in pure and its Pharmaceutical formulations. The method was based on the measurement of absorbance of Cefuroxime active moiety of Cefuroxime tablet at 277 nm using methanol as solvent. The absorbance was found to increase linearly with increase in concentration of Cefuroxime which was corroborated by correlation coefficient values. The standard solution of Cefuroxime obeyed Beer’s law over the concentration range of 9.20–27.60 µg/mL. The method is linear (from 9.20-27.60 µg/mL) with an R2 of 0.999, accurate (% recovery 100.56%) and precise (% RSD 0.316%). The method is specific and robust for Cefuroxime.

Key words: Cefuroxime, Spectrophotometric method, validation, accuracy


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