DOI: 10.21276/ajptr
Sat, 25 May 2019

Quantitative determination of Domperidone and Ranitidine in combined dosage form by FT-IR spectroscopy


P. Ravi Prasad*1, K. Bhuvaneswari1, Murarilal1, K. Rajani1

1. Analytical Chemistry Division, Indian Institute of Chemical Technology,Hyderabad-500607, India.




A simple and rapid method has been developed for the quantification of Domperidone (DMP) and Ranitidine (RAN) through FT-IR in combined dosage form. The method involves the measurement of peaks of amine (-NH) at 1620 cm-1 (RAN) and carbonyl group (C=O) at 1717 cm-1 (DMP). The method was validated for pharmaceuticals in tablet form and found to be precise with high recovery levels (>99%).

Key words: FT-IR, Ranitidine, Domperidone, combined dosage form.

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