Mon, 20 Nov 2017

Synthesis and Antimicrobial Studies of Some New Perbenzoylated N-Glucosyl Benzothiazolyl Carbamides and Carbamates

Sagar M. Jain1* Shirish P. Deshmukh2

1. Dept. of Chemistry, College of Engineering and Technology, Babhulgaon, Akola, (M.S.), India

2. P.G. Dept. of Chemistry, Shri Shivaji College, Akola -444001, (M.S.), India


ABSTRACT

 

As part of ongoing studies in developing new antimicrobials, a class of structurally novel perbenzolylated glucosyl benzothiazolyl carbamides and carbamates were synthesized by the interaction of tetra-O-benzoyl-β-D-glucosyl isocyanate with substituted benzothiazoles and various alcohols. The identities of these newly synthesized compounds were established on the basis of usual chemical transformations and IR, 1H NMR, and Mass spectral studies and evaluated for their in vitro antimicrobial activities using standard cup plate method against bacteria E. coli, P. aeruginosa, P. vulgaris, B. cereus, S. aureus and fungi A. niger, C. albicans.

Keywords: Benzothiazolyl Carbamides, Carbamates, Antimicrobial activities.


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