Mon, 20 Nov 2017

Development and Validation of Solvent Extraction Spectrophotometric Method for Simultaneous Estimation of Doxofylline and Terbutaline sulphate In their Combined Dosage Form

 

Maulik Oza1*, Jagdish Kakadiya1, Chirag Oza2

1. Pharmacy Department, Indubhai Patel College of Pharmacy and Research Centre, Dharmaj, Petlad-Khambhat road, Anand, Gujarat, India.

2. Research Scientist, Xylopia Lab., Satellite, Ahmedabad -380015, Gujarat, India.


 

ABSTRACT

Simple, specific, accurate, precise and reproducible method have been developed and validated for the simultaneous estimation of both drugs in their combined dosage form. UV spectrophotometric method was a determination using the solvent extraction method at 277 nm and 279 nm over the concentration range 10-50 and 20-60 μg/ml for Doxofylline in chloroform and terbutaline sulphate in water respectively. The % recoveries of the both the drugs were found to be 100.34% – 100.72 % and 98.25– 99.19 % respectively. Method was statistically validated for accuracy, precision, specificity, LOQ, robustness and ruggedness according to ICH guidelines and can be used for analysis of combined dosage form.

Key words: Doxofylline, Terbutaline sulphate, Solvent Extraction Spectrophotometric method.


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