Mon, 20 Nov 2017

Evaluation of analgesic activity of crude methanolic extract of Sciaenidae fishes. (Nibea maculata and Johnius dussumieri)

 

Malarvizhi. R1. V. Anandhan1, V. Muthuviveganandavel2 ⃰          

1. Dept. of Zoology, Kanchi Mamunivar Centre for Post-Graduate Studies, Puducherry-8, India.

2. Dept. of Zoology, Tagore Arts College, Puducherry-8, India.


 

ABSTRACT

 

The main objective of the present investigation is to evaluate the analgesic activity of methanolic extract of Nibea maculata and Johnius dussumieri on mice. Analgesic activity of methanolic extract of Nibea maculata and Johnius dussumieri at a dose of 50 mg/Kg and 100 mg /Kg were evaluated against drug pentazocine at a dose of 5 mg/Kg. Adult Swiss albino mice of either sex of six numbers in each group were under taken for study and evaluated by tail flick and tail immersion method. The both doses of Nibea maculata crude methanolic extract and Johnius dussumieri crude methanolic extract were found to produce significant (P<0.05) analgesic activity. In tail flick method the extract at 50 mg/Kg showed significant activity (P<0.05) after 45 minutes, but in tail immersion method, the extract showed significant activity at all tested dose levels after 30 minutes interval. The result showed significant analgesic activity against stimuli.

Keywords: Nibea maculate, Johnius dussumieri, Crude methanolic extract, Tail flick method, Tail immersion test, Pentazocine.

 


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