Mon, 20 Nov 2017

Synthesis and Biological Evaluation of Some Piperazine Derivatives

 

Ravitas Deshmukh*1

1. Shri Shankaracharya Institute of Pharmaceutical Science, Bhilai (C.G.)


 

ABSTRACT

 

A series of substituted piperazine derivatives have been synthesized and tested for antibacterial activity. The antibacterial activity was tested against Gram-positive and Gram-negative bacteria strains like B. subtilis, B. pumillis, E. coli, and P. aeruginosa . These entire compounds have been characterized by their IR and 1H NMR spectral data. All synthesized compounds showed significant activity against bacterial strains. The biological screening showed that the compounds Vc, Vd and Ve are the most active ones showing an interesting antibacterial activity.

Keywords: Antibacterial activity, Piperazine, Gram negative microorganism, Gram positive microorganism


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