Tue, 19 Dec 2017

A Review on Alzheimer’s Disease: Pathogenesis and Management

 

Bibekananda Meher1*, Deepak Kumar. Dash2, Rajib Lochan Maharana3, Sumi Jose1

1.Columbia Institute of Pharmacy Raipur, C G-493111

2.Royal College of Pharmacy Sciences, Raipur, CG-492099

3.Roland Institute of Pharmaceutical Sciences, Berhampur, Odisha- 760010


 

ABSTRACT

Alzheimer’s disease is the most prevalent form of dementia. Neuropathogenesis is proposed to be a result of the accumulation of amyloid β- peptides in the brain together with oxidative stress mechanisms and neuroinflammation. Drugs effective in Alzheimer’s disease (AD) should have several aims: to improve the cognitive impairment, control the behavioral and neurological symptoms, delay the progression of the disease, and prevent the onset. This review discusses the molecular mechanism of Alzheimer’s disease with a focus on the different agents those are inhibit the progression of the disease and improved patients condition and status..

Key words: Alzheimer’s disease, β-amyloid, Tacrine, Rivastigmine


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