Tue, 19 Dec 2017

A Review on Floating Multiparticulate System For Gastric Retention

 

Mansi Sharma*1, Ashwani Kumar Chaturvedi1, UmeshKumar Singh1, RamDayal Gupta1, Ashwini Gulati1, Prateek Sehgal1

1.Kharvel Subharti College of Pharmacy, Subharti University, Meerut, U.P., India pin 250005


 

 

 

ABSTRACT

Over the years, different formulation technologies for gastroretentive dosage delivery were investigated and patented. Well-designed controlled drug delivery system can overcome the problems of conventional therapy and enhance the therapeutic efficacy of a drug. There are various approaches in delivering a therapeutic substance to target site in a sustained controlled release fashion. One such approach is using multiparticulate as carriers for drugs. Such systems have advantages over single-unit dosage forms as they avoid the all-or-none gastric emptying nature of single-unit systems. However, multiparticulate dosage forms are gaining favor because of potential benefits like predictable gastric emptying, no risk of dose dumping, flexible release patterns and increased bioavailability with less inter- and intra-subject variability. The purpose of writing this review on method of prepare floating multiparticulate is to compile the recent literature with special focus on the classification and formulation aspects, principal mechanism of floatation to achieve gastric retention, characterization of floating multiparticulate system.

Keywords- multiparticulate system, design and method of preparation, floating microspheres, beads, granules.

 

 


[PDF]  Viewed: 1098  Downloaded: 171
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter