DOI: 10.21276/ajptr
Mon, 25 Mar 2019

Catalepsy, A Scientific Model For Exploring Unani Herbs Having Possible Specificity for Different Neurotransmitters: A Review.


Pervaiz A. Dar* 1, Shabir A Parray1, G. Sofi2, M. A. Jafri3

1. Department of Phytochemistry & Pharmacognosy, Faculty of Pharmacy, Jamia Hamdard, New Delhi (India)

2. Department of Ilmul Advia, National Institute of Unani Medicine, Bangalore,Karnataka (India)

3. Department of Ilmul Advia,, Faculty of Unani Medicine, Jamia Hamdard, New Delhi (India)



One of the challenges faced by scientific community is that of adverse and deterioting side effects of psychotropic agents, which are popularly known as neuroleptic induced extrapyramidal adverse effects. Neuroleptic induced movement disorders pose a significant burden to patients, often resulting in non-adherence, disease relapse, and decreased quality of life. Evidence indicates that drugs which potentiate or attenuate neuroleptic induced catalepsy in rodents might aggravate or reduce the extrapyramidal signs respectively in human beings. It is being appreciated that many plant drugs can be explored for their protective nature against such adverse and toxic effects on account of their ascribed effects.

Keywords: Neuroleptic, Catalepsy, Unani medicine, Extrapyramidal, Dopamine

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