DOI: 10.21276/ajptr
Mon, 25 Mar 2019

Nanofibers In Pharmaceuticals - A Review


S Bharat Kumar. Kattamuri*1, Lakshmanarao Potti1, Anjaneyulu Vinukonda1, Veeranjaneyulu Bandi1, Sreeram Chagantipati2, Mogili RK1

1.Department of Pharmaceutics, M.A.M College of Pharmacy,Kesanupalli, Narasaraopet, Guntur (Dt), Andhra Pradesh,India.

2. Department of Pharmaceutics, Narasaraopet institute of pharmaceutical sciences  Narasaraopet, Guntur (Dt), Andhra Pradesh, India.



Unique properties of Nanofibers have attracted for the designing of controlled drug delivery systems due to high surface area to volume ratio, porosity so only we can applied in advance application such as Biodegradable and controlled drug delivery systems. The benefits of the fibrous carriers are site specific delivery of drugs to the body. Nanofibers are an exciting new class of material produced using an innovative manufacturing process technology. These fibers are produced from a variety of polymers in geometrical shapes ranging from Nonwoven web, yarn, and bulk structures. The Synthetic polymer Nanofibers are made from Nylon, Acrylic, Polycarbonate, Polysulfones, and Fluro polymers among other polymers. The biological polymer nanofibers are made from materials such as Polycaprolactum, Chitosan, Polylactic acid, and Copolymer of Polylactic/glycolic acid among other biopolymers. At present, there are three techniques available for the synthesis of Nanofibers: Electro spinning, self-assembly, and phase separation, out of these Electro spinning is the most widely used technique. Mostly , the bioactive molecules like anti-cancer drugs, enzymes. Cytokines, and polysaccharides can be entrapped within the interior or physically immobilized on the surfaces of nanofiber for controlled drug delivery. The advanced approach for creating Nanofibers made of proteins developed, greatly improve drug delivery methods for the treatment of cancers, heart, and Alzheimer’s diseases, as well as aid in the regeneration of human tissue, bone and cartilage. This review paper reports on fabrication of nanofibers and its characteristics and high tech application in drug delivery, tissue engineering and filter medium.

Keywords: Electro spinning, controlled drug delivery, Fabrication, characterization, applications.

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