DOI: 10.21276/ajptr
Mon, 25 Mar 2019

Phytochemical and Biological Investigation on Artocarpus lackoocha Roxb.


F.T.Zohora1, P. Sarkar1, F.S. Tareq2, S.N.Islam3, C.M. Hasan1*, M. Ahsan1

1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh.

2. Department of Applied Chemistry, University of Dhaka, Dhaka-1000, Bangladesh.

3. Institute of Nutrition and food science, University of Dhaka, Dhaka-1000, Bangladesh.



Mixture of three compounds lupeol acetate (1), alpha amyrin acetate(2) and beta amyrin acetate(3) were isolated from the methanolic extract of the stem bark of Artocarpus lackoocha Roxb.(Family: Moraceae).The crude methanol extract as well as its petroleum ether, carbon tetrachloride; chloroform and aqueous soluble Kupchan fractions were studied for antioxidant, antimicrobial and cytotoxic activities. Among the different fractions tested for antioxidant activity, the aqueous soluble partitionate was the most potent with IC50 value of 3.47μg/ml as compared to tertbutyl-1-hydroxytoluene (IC50=27.54μg/ml). Antimicrobial screening of the different extractives was conducted by the disc diffusion method and the crude methanol extract as well as aqueous soluble fractions exhibited moderate antimicrobial activity with zone of inhibition ranging from 7-12 mm. In brine shrimp lethality bioassay, the aqueous soluble materials demonstrated the highest toxicity with LC50 of 1.6μg/ml. β-amyrin acetate is the first report of isolation of compounds from Artocarpus lackoocha.

Keywords: Artocarpus lackoocha, chemical constituents, antioxidant, antimicrobial, cytotoxicity.

[PDF]   Viewed: 1484   Downloaded: 140
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.



  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.


  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.


web counter
web counter