Tue, 19 Dec 2017

Spectrophotometric Estimation of Benazepril by Calibration Curve Method

 

Hemlata M. Nimje*1, Rajesh J. Oswal2, Nilima M. Nimje3, Sunil K. Chandane2, Sampada S. Jangam2

1.Nims University, Shobha Nagar, Jaipur-303121

2.JSPM’s Charak College of Pharmacy and Research, Pune-Nagar road, Wagholi, Pune

3.University Department of Pharmaceutical Science, Nagpur-400 033.


 

ABSTRACT

The objective of this work was to develop and validate simple, rapid and accurate spectrophotometric method for quantitative estimation of Benazepril in pure drug. Benazepril is used for management of hypertension, heart failure, myocardial infarction. In methanol Benazepril exhibits absorption at 242.4 nm and method obeys Beer’s law at the concentration range of 2.0-100 µg/mL. The percentage label claim was found in the range of 98-103%. The proposed method was validated statistically and by recovery studies.

Keywords: UV Spectrophotometer, Calibration curve method, Benazepril tablet


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