Tue, 19 Dec 2017

Formulation and Evaluation of Controlled Release Floating Tablet of Perindopril Erbumine using Natural Polymer

 

Balkrushna K. Patel 1*, Paresh U. Patel 2

1.K.J.College of Pharmacy, At & Post Vadasma, Ta.& Dist. Mehsana, Gujarat, India

2. SKPCPER, Ganpat University, Ganpat Vidhyanagar, Mehsana, Gujarat, India.


 

ABSTRACT

Floating dosage form for gastric retention has potential to use as controlled-release drug delivery systems which providing opportunity for both local and systemic drug action. The present work was aimed to formulate controlled release floating tablet (CRFT) of Perindopril Erbumine using gas generated low density approach. To develop CRFT, the Perindopril Erbumine was selected as a drug because it complies with the suitability criteria for the floating drug delivery system and the controlled release medication was required due to its potent action and poor bioavailability. The present investigation was suggested that the bioavailability of Perindopril Erbumine was improved due to increased gastric retention time and controlling the drug release rate using the natural polymer SFG, HPMCK15M and Acrypol 934. The CRFT of Perindopril Erbumine was developed by using wet granulation method and PVP K 30 was used as a granulating agent. The study was given the assurance that SFG had an excellent controlled drug releasing property then HPMCK15M by forming matrix in the formulation. The Acrypol 934 was added to control the drug release rate in to formulation and found good compressibility and controllable drug releasing properties in to the final formulation. All the formulation was evaluated for Weight variation, Thickness, Hardness, Diameter, Friability, Assay, FLT, TFT, Swelling Index and Dissolution study.

Key Word: CRFT, SFG, Acrypol 934, FLT, TFT, SWI, Perindopril Erbumine, DSC


[PDF]  Viewed: 2317  Downloaded: 401
  • Call for paper

    American Journal of PharmTech Research (AJPTR) is a peer-reviewed, bimonthly official international journal allowing access to abstracts and full-text.

    Read more...

     

  • Email & SMS Alerts

    Email/SMS alert system is one of the key features and gives update information about the submitted manuscript.

    Read more...

  • Article Statastics

    American Journal of PharmTech Research (AJPTR) provides unique facility for authors to know popularity of articles on basis of numbers of PDF download and views. It will display in tabulated format.

  • Online Submission

    American Journal of PharmTech Research (AJPTR) is one of the International open access journal devoted to various disciplines in science and technology.

    Read more...

web counter
web counter