Tue, 19 Dec 2017

Protective effects of Aegel Marmelos leaves extracts against Carbon Tetrachloride induced Hepatotoxicity in rats.

 

Hiral K Modi*1, Vishnu M Patel2, Shweta M Bhadani3

1.Research Scholar, JJT University, Jhunjhunu, Rajasthan – 333001, India

2.APMC College of Pharmaceutical Education & Research , Himatnagar, Gujarat, India

3.Saraswati Institute of Pharmaceutical Sciences, Chiloda, Gandhinagar –382355, India


 

ABSTRACT

To evaluate the heapatoprotective activity of various extracts of Aegle Marmelos, belonging to the family Rutaceae against Carbon Tetrachloride (CCL) induced hepatootxicity in wistar Female rats. Oxidative stress play important role in many diseases. Hence, Herbal drugs play crucial role in treatment of various diseases due to its antioxidant property. The toxicant was used to induce hepatotoxicity at dose of CCl1.25 ml/kg of body weight as mixture of 1:1 with olive oil for 30 days. Experimental groups of were constructed: a vehicle control group received the respective vehicles; a CCl4 group received a repeated single oral dose of CCl4 at 1.25 ml/kg; and the CCl4 &AMPE, AMCL.AMAL, AMAQ received repeated oral dose of Aegel Marmelos extracts in 500 mg/kg, respectively. It was found that AMCL, AMAL & AMAQ, at a dose of 500 mg/kg body weight exhibited hepatoprotective effect by lowering the Serum Glutamate Pyruvate Transaminase (SGPT), Serum Glutamate Oxaloacetate Transaminase (SGOT), alkaline phosphate and total bilirubin to a significant extent. The groups treated with various extract of A.Marmelos & Silyamarine shows significant (P<0.001) restoration of liver weight & liver volume nearer to normal control group. Since results of biochemical studies of blood samples of Aegle Marmelos Extracts treated rats showed significant decrease in the levels of serum enzyme activities, reflecting the liver injury caused by CCL4 indicating the protection of hepatic cells against CCL4 induced hepatocellular injury. The effects of Aegel Marmelos extracts were comparable with standard drug silymarin.

Key words: Aegle Marmelos; CCl4 (Carbon Tetrachloride); Heaptotoxicity; Oxidative Stress; Protective Effects.


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